Allergic Aspects of IgG4-Related Disease: Implications for Pathogenesis and Therapy

Allergic Aspects of IgG4-Related Disease: Implications for Pathogenesis and Therapy

Blog Article

IgG4-related disease (IgG4-RD) is a rare systemic fibroinflammatory disease frequently associated with allergy.The pathogenesis of IgG4-RD is poorly understood, hp pavilion 15-eg1053cl and effective therapies are limited.However, IgG4-RD appears to involve some of the same pathogenic mechanisms observed in allergic disease, such as T helper 2 (Th2) and regulatory T cell (Treg) activation, IgG4 and IgE hypersecretion, and blood/tissue eosinophilia.In addition, IgG4-RD tissue fibrosis appears to involve activation of basophils and mast cells and their release of alarmins and cytokines.In this article, we review allergy-like features of IgG4-RD and highlight targeted therapies for allergy that have potential here in treating patients with IgG4-RD.